3CKP
Crystal structure of BACE-1 in complex with inhibitor
Summary for 3CKP
Entry DOI | 10.2210/pdb3ckp/pdb |
Related | 3CKR |
Descriptor | Beta-secretase 1, CHLORIDE ION, (4S)-N-[(1S,2R)-1-benzyl-3-{[3-(dimethylamino)benzyl]amino}-2-hydroxypropyl]-1-(3-methoxybenzyl)-2-oxoimidazolidine-4-carboxamide, ... (4 entities in total) |
Functional Keywords | beta-secretase, aspartyl protease, alternative splicing, glycoprotein, hydrolase, membrane, transmembrane, zymogen |
Biological source | Homo sapiens (Human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 3 |
Total formula weight | 139726.73 |
Authors | |
Primary citation | Park, H.,Min, K.,Kwak, H.-S.,Koo, K.D.,Lim, D.,Seo, S.-W.,Choi, J.-U.,Platt, B.,Choi, D.-Y. Synthesis, SAR, and X-ray structure of human BACE-1 inhibitors with cyclic urea derivatives Bioorg.Med.Chem.Lett., 18:2900-2904, 2008 Cited by PubMed: 18434152DOI: 10.1016/j.bmcl.2008.03.081 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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