3CKI

Crystal structure of the TACE-N-TIMP-3 complex

3CKI の概要

• エントリーDOI: 10.2210/pdb3cki/pdb
• 分子名称: ADAM 17, Metalloproteinase inhibitor 3, ZINC ION, ... (5 entities in total)
• 機能のキーワード: extra-cellular matrix, catalytic zinc, sa-sb loop, alternative splicing, cleavage on pair of basic residues, glycoprotein, membrane, metal-binding, metalloprotease, notch signaling pathway, phosphoprotein, protease, sh3-binding, transmembrane, zymogen, disease mutation, extracellular matrix, metalloenzyme inhibitor, metalloprotease inhibitor, secreted, sensory transduction, vision, hydrolase, hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P78536; Secreted, extracellular space, extracellular matrix: P35625
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43016.13

構造登録者

Wisniewska, M.,Goettig, P.,Maskos, K.,Belouski, E.,Winters, D.,Hecht, R.,Black, R.,Bode, W. (登録日: 2008-03-15, 公開日: 2008-08-05, 最終更新日: 2023-08-30)

• 主引用文献: Wisniewska, M.,Goettig, P.,Maskos, K.,Belouski, E.,Winters, D.,Hecht, R.,Black, R.,Bode, W.; Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex.; J.Mol.Biol., 381:1307-1319, 2008; PubMed: 18638486; DOI: 10.1016/j.jmb.2008.06.088

実験手法

X-RAY DIFFRACTION (2.3 Å)