3CIK

Human GRK2 in Complex with Gbetagamma subunits

3CIK の概要

• エントリーDOI: 10.2210/pdb3cik/pdb
• 関連するPDBエントリー: 1BX6 1OMW 3CIL
• 分子名称: Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (5 entities in total)
• 機能のキーワード: protein kinase, complex, g protein, receptor, wd40 repeat, atp-binding, nucleotide-binding, serine/threonine-protein kinase, transferase, transducer, wd repeat, lipoprotein, membrane, phosphoprotein, prenylation, transferase-signaling protein complex, transferase/signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): P63212
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 125540.53

構造登録者

Tesmer, J.J.G.,Lodowski, D.T. (登録日: 2008-03-11, 公開日: 2009-02-17, 最終更新日: 2012-03-07)

• 主引用文献: Tesmer, J.J.,Tesmer, V.M.,Lodowski, D.T.,Steinhagen, H.,Huber, J.; Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.; J.Med.Chem., 53:1867-1870, 2010; PubMed: 20128603; DOI: 10.1021/jm9017515

実験手法

X-RAY DIFFRACTION (2.75 Å)