3CGO

IRAK-4 Inhibitors (Part II)- A structure based assessment of imidazo[1,2 a]pyridine binding

3CGO の概要

• エントリーDOI: 10.2210/pdb3cgo/pdb
• 関連するPDBエントリー: 2P33 3CGF
• 分子名称: Mitogen-activated protein kinase 10, 2-{4-[(4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]piperidin-1-yl}-N-methylacetamide (3 entities in total)
• 機能のキーワード: jnk3 kinase, inhibitor, alternative splicing, atp-binding, chromosomal rearrangement, cytoplasm, epilepsy, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : P53779
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42482.16

構造登録者

Ceska, T.A.,Platt, A.,Fortunato, M.,Dickson, K.M.,Beevers, R. (登録日: 2008-03-06, 公開日: 2008-06-03, 最終更新日: 2023-11-01)

• 主引用文献: Buckley, G.M.,Ceska, T.A.,Fraser, J.L.,Gowers, L.,Groom, C.R.,Higueruelo, A.P.,Jenkins, K.,Mack, S.R.,Morgan, T.,Parry, D.M.,Pitt, W.R.,Rausch, O.,Richard, M.D.,Sabin, V.; IRAK-4 inhibitors. Part II: A structure-based assessment of imidazo[1,2-a]pyridine binding; Bioorg.Med.Chem.Lett., 18:3291-3295, 2008; PubMed: 18482836; DOI: 10.1016/j.bmcl.2008.04.039

実験手法

X-RAY DIFFRACTION (3 Å)