3CGO
IRAK-4 Inhibitors (Part II)- A structure based assessment of imidazo[1,2 a]pyridine binding
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase 10 | polymer | 365 | 42116.7 | 1 | UniProt (P53779) Pfam (PF00069) | Homo sapiens (Human) | Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3, MAP kinase p49 3F12 |
| 2 | B (A) | 2-{4-[(4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]piperidin-1-yl}-N-methylacetamide | non-polymer | 365.4 | 1 | Chemie (JNO) | |||
| 3 | C (A) | water | water | 18.0 | 54 | Chemie (HOH) |
Sequence modifications
A: 40 - 402 (UniProt: P53779)
| PDB | External Database | Details |
|---|---|---|
| Met 38 | - | expression tag |
| Gly 39 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42116.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 365.4 | |
| All* | Total formula weight | 42482.2 |
