3CF6

Structure of Epac2 in complex with cyclic-AMP and Rap

Summary for 3CF6

Related2BYV
DescriptorRap guanine nucleotide exchange factor (GEF) 4, Ras-related protein Rap-1b, 6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL, ... (5 entities in total)
Functional Keywordsepac, rapgef4, rap, rap1b, camp, sp-camps, gef, gunanine nucleotide exchange factor, g-protein, gtp-binding, nucleotide-binding, signaling protein regulator-gtp-binding protein complex, signaling protein-gtp-binding protein complex, signaling protein/gtp-binding protein
Biological sourceMus musculus (mouse)
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Cellular locationCell membrane P61224
Total number of polymer chains2
Total molecular weight99084.95
Authors
Rehmann, H.,Arias-Palomo, E.,Hadders, M.A.,Schwede, F.,Llorca, O.,Bos, J.L. (deposition date: 2008-03-02, release date: 2008-07-29, Last modification date: 2014-02-05)
Primary citation
Rehmann, H.,Arias-Palomo, E.,Hadders, M.A.,Schwede, F.,Llorca, O.,Bos, J.L.
Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B
Nature, 455:124-127, 2008
PubMed: 18660803 (PDB entries with the same primary citation)
DOI: 10.1038/nature07187
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.26470.5%6.6%5.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution