3CEH
Human liver glycogen phosphorylase (tense state) in complex with the allosteric inhibitor AVE5688
Summary for 3CEH
Entry DOI | 10.2210/pdb3ceh/pdb |
Related | 3CEJ 3CEM |
Descriptor | Glycogen phosphorylase, liver form, N-acetyl-beta-D-glucopyranosylamine, PHOSPHATE ION, ... (7 entities in total) |
Functional Keywords | protein ligand complex, tense state, allosteric inhibitor, allosteric enzyme, carbohydrate metabolism, disease mutation, glycogen metabolism, glycogen storage disease, glycosyltransferase, nucleotide-binding, phosphoprotein, pyridoxal phosphate, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 188326.43 |
Authors | Wendt, K.U.,Dreyer, M.K.,Anderka, O.,Klabunde, T.,Loenze, P.,Defossa, E.,Schmoll, D. (deposition date: 2008-02-29, release date: 2008-05-27, Last modification date: 2020-07-29) |
Primary citation | Anderka, O.,Loenze, P.,Klabunde, T.,Dreyer, M.K.,Defossa, E.,Wendt, K.U.,Schmoll, D. Thermodynamic characterization of allosteric glycogen phosphorylase inhibitors. Biochemistry, 47:4683-4691, 2008 Cited by PubMed: 18373353DOI: 10.1021/bi702397d PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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