3CDP
Crystal structure of PPAR-gamma LBD complexed with a partial agonist, analogue of clofibric acid
Summary for 3CDP
Entry DOI | 10.2210/pdb3cdp/pdb |
Related | 1K74 3CDS |
Descriptor | Peroxisome proliferator-activated receptor gamma, (2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid (3 entities in total) |
Functional Keywords | bundle of alpha-helices and a small four-stranded beta-sheet, activator, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, receptor, transcription, transcription regulation, zinc-finger |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: P37231 |
Total number of polymer chains | 2 |
Total formula weight | 65338.02 |
Authors | Pochetti, G.,Montanari, R.,Mazza, F. (deposition date: 2008-02-27, release date: 2009-01-13, Last modification date: 2024-03-13) |
Primary citation | Fracchiolla, G.,Laghezza, A.,Piemontese, L.,Parente, M.,Lavecchia, A.,Pochetti, G.,Montanari, R.,Di Giovanni, C.,Carbonara, G.,Tortorella, P.,Novellino, E.,Loiodice, F. Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors alpha/gamma dual agonists Bioorg.Med.Chem., 20:2141-2151, 2012 Cited by PubMed: 22341573DOI: 10.1016/j.bmc.2012.01.025 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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