3CDG

Human CD94/NKG2A in complex with HLA-E

3CDG の概要

• エントリーDOI: 10.2210/pdb3cdg/pdb
• 分子名称: HLA class I histocompatibility antigen, alpha chain E, Beta-2-microglobulin, Natural killer cells antigen CD94, ... (5 entities in total)
• 機能のキーワード: nk cell receptor, immunity, c-type lectin, mhc, glycoprotein, immune response, membrane, mhc i, polymorphism, transmembrane, disease mutation, glycation, immunoglobulin domain, pyrrolidone carboxylic acid, secreted, alternative splicing, signal-anchor, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P13747 P17693; Secreted: P61769; Membrane; Single-pass type II membrane protein: Q13241 P26715
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 145509.85

構造登録者

Petrie, E.J.,Clements, C.S.,Lin, J.,Sullivan, L.C.,Johnson, D.,Huyton, T.,Heroux, A.,Hoare, H.L.,Beddoe, T.,Reid, H.H.,Wilce, M.C.J.,Brooks, A.G.,Rossjohn, J. (登録日: 2008-02-26, 公開日: 2008-04-22, 最終更新日: 2023-11-01)

• 主引用文献: Petrie, E.J.,Clements, C.S.,Lin, J.,Sullivan, L.C.,Johnson, D.,Huyton, T.,Heroux, A.,Hoare, H.L.,Beddoe, T.,Reid, H.H.,Wilce, M.C.J.,Brooks, A.G.,Rossjohn, J.; CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence; J.Exp.Med., 205:725-735, 2008; PubMed: 18332182; DOI: 10.1084/jem.20072525

実験手法

X-RAY DIFFRACTION (3.4 Å)