3CD3

Crystal structure of phosphorylated human feline sarcoma viral oncogene homologue (v-FES) in complex with staurosporine and a consensus peptide

3CD3 の概要

• エントリーDOI: 10.2210/pdb3cd3/pdb
• 関連するPDBエントリー: 3CBL
• 分子名称: Proto-oncogene tyrosine-protein kinase Fes/Fps, Synthetic peptide, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: fes, v-fes, fujinami, avian sarcoma, viral, oncogene, feline sarcoma virus, active, sgc, structural genomics consortium, atp-binding, kinase, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, transferase, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 44958.26

構造登録者

Filippakopoulos, P.,Salah, E.,Cooper, C.,Picaud, S.S.,Elkins, J.M.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2008-02-26, 公開日: 2008-03-25, 最終更新日: 2023-11-15)

• 主引用文献: Filippakopoulos, P.,Kofler, M.,Hantschel, O.,Gish, G.D.,Grebien, F.,Salah, E.,Neudecker, P.,Kay, L.E.,Turk, B.E.,Superti-Furga, G.,Pawson, T.,Knapp, S.; Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation; Cell(Cambridge,Mass.), 134:793-803, 2008; PubMed: 18775312; DOI: 10.1016/j.cell.2008.07.047

実験手法

X-RAY DIFFRACTION (1.98 Å)