3CD0

Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors

3CD0 の概要

• エントリーDOI: 10.2210/pdb3cd0/pdb
• 関連するPDBエントリー: 3CCT 3CCW 3CCZ 3CD5 3CD7 3CDA 3CDB
• 分子名称: 3-hydroxy-3-methylglutaryl-coenzyme A reductase, (3R,5R)-7-{2-[(4-fluorobenzyl)carbamoyl]-4-(4-fluorophenyl)-1-(1-methylethyl)-1H-imidazol-5-yl}-3,5-dihydroxyheptanoic acid (3 entities in total)
• 機能のキーワード: oxidoreductase, cholesterol biosynthesis, hmg-coa, nadph, statin, alternative splicing, endoplasmic reticulum, glycoprotein, lipid synthesis, membrane, peroxisome, polymorphism, steroid biosynthesis, transmembrane
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Endoplasmic reticulum membrane; Multi-pass membrane protein: P04035
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 191980.40

構造登録者

Pavlovsky, A.,Sarver, R.W.,Harris, M.S.,Finzel, B.C. (登録日: 2008-02-26, 公開日: 2008-06-17, 最終更新日: 2024-02-21)

• 主引用文献: Sarver, R.W.,Bills, E.,Bolton, G.,Bratton, L.D.,Caspers, N.L.,Dunbar, J.B.,Harris, M.S.,Hutchings, R.H.,Kennedy, R.M.,Larsen, S.D.,Pavlovsky, A.,Pfefferkorn, J.A.,Bainbridge, G.; Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase.; J.Med.Chem., 51:3804-3813, 2008; PubMed: 18540668; DOI: 10.1021/jm7015057

実験手法

X-RAY DIFFRACTION (2.4 Å)