3CD7

Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors

Summary for 3CD7

Entry DOI	10.2210/pdb3cd7/pdb
Related	3CCT 3CCW 3CCZ 3CD0 3CD5 3CDA 3CDB
Descriptor	3-hydroxy-3-methylglutaryl-coenzyme A reductase, (3R,5R)-7-[5-(ANILINOCARBONYL)-3,4-BIS(4-FLUOROPHENYL)-1-ISOPROPYL-1H-PYRROL-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID (3 entities in total)
Functional Keywords	oxidoreductase, cholesterol biosynthesis, hmg-coa, nadph, statin, alternative splicing, endoplasmic reticulum, glycoprotein, lipid synthesis, membrane, peroxisome, polymorphism, steroid biosynthesis, transmembrane
Biological source	Homo sapiens (Human)
Cellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein: P04035
Total number of polymer chains	4
Total formula weight	192224.72
Authors	Pavlovsky, A.,Sarver, R.W.,Harris, M.S.,Finzel, B.C. (deposition date: 2008-02-26, release date: 2008-06-17, Last modification date: 2024-02-21)
Primary citation	Sarver, R.W.,Bills, E.,Bolton, G.,Bratton, L.D.,Caspers, N.L.,Dunbar, J.B.,Harris, M.S.,Hutchings, R.H.,Kennedy, R.M.,Larsen, S.D.,Pavlovsky, A.,Pfefferkorn, J.A.,Bainbridge, G. Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase. J.Med.Chem., 51:3804-3813, 2008 Cited by PubMed: 18540668 DOI: 10.1021/jm7015057 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation