3CAV
Crystal structure of 5beta-reductase (AKR1D1) in complex with NADP+ and 5beta-pregnan-3,20-dione
Summary for 3CAV
Entry DOI | 10.2210/pdb3cav/pdb |
Related | 3CAQ 3CAS |
Descriptor | 3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (5BETA)-PREGNANE-3,20-DIONE, ... (6 entities in total) |
Functional Keywords | 5b-reductase, 5beta-reductase, 5b-red, akr1d1, akr, aldo-keto reductase, nadp, androstenedione. nadph, bile acid catabolism, cytoplasm, disease mutation, lipid metabolism, oxidoreductase, steroid metabolism |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P51857 |
Total number of polymer chains | 2 |
Total formula weight | 77442.17 |
Authors | Faucher, F.,Cantin, L.,Breton, R. (deposition date: 2008-02-20, release date: 2008-07-29, Last modification date: 2011-07-13) |
Primary citation | Faucher, F.,Cantin, L.,Luu-The, V.,Labrie, F.,Breton, R. The crystal structure of human Delta4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism. Biochemistry, 47:8261-8270, 2008 Cited by PubMed: 18624455DOI: 10.1021/bi800572s PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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