3CAV

Crystal structure of 5beta-reductase (AKR1D1) in complex with NADP+ and 5beta-pregnan-3,20-dione

3CAV の概要

• エントリーDOI: 10.2210/pdb3cav/pdb
• 関連するPDBエントリー: 3CAQ 3CAS
• 分子名称: 3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (5BETA)-PREGNANE-3,20-DIONE, ... (6 entities in total)
• 機能のキーワード: 5b-reductase, 5beta-reductase, 5b-red, akr1d1, akr, aldo-keto reductase, nadp, androstenedione. nadph, bile acid catabolism, cytoplasm, disease mutation, lipid metabolism, oxidoreductase, steroid metabolism
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P51857
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 77442.17

構造登録者

Faucher, F.,Cantin, L.,Breton, R. (登録日: 2008-02-20, 公開日: 2008-07-29, 最終更新日: 2011-07-13)

• 主引用文献: Faucher, F.,Cantin, L.,Luu-The, V.,Labrie, F.,Breton, R.; The crystal structure of human Delta4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism.; Biochemistry, 47:8261-8270, 2008; PubMed: 18624455; DOI: 10.1021/bi800572s

実験手法

X-RAY DIFFRACTION (1.9 Å)