3C7I
X-RAY crystal structure of the complex between the grb2-sh2 domain and a flexible ligand, FPTVN.
Replaces: 2HUYSummary for 3C7I
| Entry DOI | 10.2210/pdb3c7i/pdb |
| Related | 2HUW |
| Descriptor | Growth factor receptor-bound protein 2, N-{(2R)-4-(methylamino)-4-oxo-2-[4-(phosphonooxy)benzyl]butanoyl}-L-valyl-L-aspartamide, FORMIC ACID, ... (4 entities in total) |
| Functional Keywords | flexible, constrained, entropy, grb2-sh2, ligand preorganization, alternative splicing, host-virus interaction, phosphoprotein, sh2 domain, sh3 domain, splicing |
| Biological source | Homo sapiens (Human) |
| Cellular location | Golgi apparatus (By similarity): P62993 |
| Total number of polymer chains | 1 |
| Total formula weight | 14262.97 |
| Authors | Benfield, A.P.,Martin, S.F. (deposition date: 2008-02-07, release date: 2008-08-12, Last modification date: 2024-02-21) |
| Primary citation | Benfield, A.P.,Teresk, M.G.,Plake, H.R.,Delorbe, J.E.,Millspaugh, L.E.,Martin, S.F. Ligand Preorganization May be Accompanied by Entropic Penalties in Protein-Ligand Interactions. Angew.Chem.Int.Ed.Engl., 118:6984-6989, 2006 Cited by PubMed: 17001728DOI: 10.1002/ange.200600844 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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