3C45

Human dipeptidyl peptidase IV/CD26 in complex with a fluoroolefin inhibitor

3C45 の概要

• エントリーDOI: 10.2210/pdb3c45/pdb
• 関連するPDBエントリー: 1x70 2hha 2iit 2iiv 2oph 3C43
• 分子名称: Dipeptidyl peptidase 4 soluble form, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: alpha/beta, beta-propeller, dimer, aminopeptidase, glycoprotein, hydrolase, membrane, protease, secreted, serine protease, signal-anchor, transmembrane
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 175031.06

構造登録者

Scapin, G.,Edmondson, S.D.,Weber, A.E. (登録日: 2008-01-29, 公開日: 2008-04-22, 最終更新日: 2023-08-30)

• 主引用文献: Edmondson, S.D.,Wei, L.,Xu, J.,Shang, J.,Xu, S.,Pang, J.,Chaudhary, A.,Dean, D.C.,He, H.,Leiting, B.,Lyons, K.A.,Patel, R.A.,Patel, S.B.,Scapin, G.,Wu, J.K.,Beconi, M.G.,Thornberry, N.A.,Weber, A.E.; Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors; Bioorg.Med.Chem.Lett., 18:2409-2413, 2008; PubMed: 18331795; DOI: 10.1016/j.bmcl.2008.02.050

実験手法

X-RAY DIFFRACTION (2.05 Å)