3C09
Crystal structure the Fab fragment of matuzumab (Fab72000) in complex with domain III of the extracellular region of EGFR
Summary for 3C09
Entry DOI | 10.2210/pdb3c09/pdb |
Related | 3C08 |
Descriptor | Matuzumab Fab Light chain, Matuzumab Fab Heavy chain, Epidermal growth factor receptor, ... (6 entities in total) |
Functional Keywords | cell surface receptor, glycoprotein, antigen, antibody complex, fab fragment, antitumor, drug immune system-transferase complex, immune system-transferase complex, immune system/transferase |
Biological source | Mus musculus (house mouse) More |
Total number of polymer chains | 6 |
Total formula weight | 144883.62 |
Authors | Ferguson, K.M.,Schmiedel, J.,Knoechel, T. (deposition date: 2008-01-18, release date: 2008-04-15, Last modification date: 2023-11-01) |
Primary citation | Schmiedel, J.,Blaukat, A.,Li, S.,Knochel, T.,Ferguson, K.M. Matuzumab binding to EGFR prevents the conformational rearrangement required for dimerization. Cancer Cell, 13:365-373, 2008 Cited by PubMed: 18394559DOI: 10.1016/j.ccr.2008.02.019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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