3BXM

Structure of an inactive mutant of human glutamate carboxypeptidase II [GCPII(E424A)] in complex with N-acetyl-Asp-Glu (NAAG)

3BXM の概要

• エントリーDOI: 10.2210/pdb3bxm/pdb
• 分子名称: Glutamate carboxypeptidase 2, N-Acetyl-Aspartyl-Glutamate (NAAG), 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• 機能のキーワード: protein-substrate complex, carboxypeptidase, dipeptidase, glycoprotein, hydrolase, membrane, metal-binding, metalloprotease, multifunctional enzyme, protease, signal-anchor, transmembrane
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm: Q04609
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 82981.10

構造登録者

Lubkowski, J.,Barinka, C. (登録日: 2008-01-14, 公開日: 2009-01-27, 最終更新日: 2023-08-30)

• 主引用文献: Klusak, V.,Barinka, C.,Plechanovova, A.,Mlcochova, P.,Konvalinka, J.,Rulisek, L.,Lubkowski, J.; Reaction mechanism of glutamate carboxypeptidase II revealed by mutagenesis, X-ray crystallography, and computational methods.; Biochemistry, 48:4126-4138, 2009; PubMed: 19301871; DOI: 10.1021/bi900220s

実験手法

X-RAY DIFFRACTION (1.71 Å)