3BUO
Crystal structure of c-Cbl-TKB domain complexed with its binding motif in EGF receptor'
3BUO の概要
エントリーDOI | 10.2210/pdb3buo/pdb |
関連するPDBエントリー | 3BUM 3BUN 3BUW 3BUX |
分子名称 | 13-meric peptide from Epidermal growth factor receptor, E3 ubiquitin-protein ligase CBL (3 entities in total) |
機能のキーワード | cbl, tkb, ligase, signal transduction, proto-oncogene, complex, anti-oncogene, atp-binding, cell cycle, disease mutation, glycoprotein, kinase, membrane, nucleotide-binding, phosphoprotein, receptor, secreted, transferase, transmembrane, tyrosine-protein kinase, metal-binding, sh2 domain, ubl conjugation pathway, zinc-finger, ligase-signaling protein complex, ligase/signaling protein |
由来する生物種 | Homo sapiens (human) 詳細 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 79491.18 |
構造登録者 | Ng, C.,Jackson, R.A.,Buschdorf, J.P.,Sun, Q.,Guy, G.R.,Sivaraman, J. (登録日: 2008-01-03, 公開日: 2008-02-26, 最終更新日: 2023-11-15) |
主引用文献 | Ng, C.,Jackson, R.A.,Buschdorf, J.P.,Sun, Q.,Guy, G.R.,Sivaraman, J. Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27:804-816, 2008 Cited by PubMed: 18273061DOI: 10.1038/emboj.2008.18 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.6 Å) |
構造検証レポート
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