3BUO
Crystal structure of c-Cbl-TKB domain complexed with its binding motif in EGF receptor'
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | 13-meric peptide from Epidermal growth factor receptor | polymer | 13 | 1553.5 | 2 | UniProt (P00533) | Homo sapiens | Receptor tyrosine-protein kinase ErbB-1, EGFR |
| 2 | B, D (B, D) | E3 ubiquitin-protein ligase CBL | polymer | 329 | 38192.1 | 2 | UniProt (P22681) Pfam (PF02262) Pfam (PF02761) Pfam (PF02762) | Homo sapiens (human) | Signal transduction protein CBL, Proto-oncogene c-CBL, Casitas B-lineage lymphoma proto-oncogene, RING finger protein 55 |
| 3 | E, F, G, H (A, B, C, D) | water | water | 18.0 | 235 | Chemie (HOH) |
Sequence modifications
B, D: 23 - 351 (UniProt: P22681)
| PDB | External Database | Details |
|---|---|---|
| Ser 24 | Gly 24 | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 79491.2 | |
| All* | Total formula weight | 79491.2 |
