3BUH

BACE-1 complexed with compound 4

Summary for 3BUH

Entry DOI	10.2210/pdb3buh/pdb
Related	3BRA 3BUF 3BUG
Descriptor	beta-secretase 1, 4-(2-aminoethyl)-2-cyclohexylphenol (3 entities in total)
Functional Keywords	alzheimer's disease, aspartic protease, beta-secretase, memapsin 2, fragment screen, alternative splicing, aspartyl protease, glycoprotein, hydrolase, membrane, transmembrane, zymogen
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P56817
Total number of polymer chains	1
Total formula weight	45773.33
Authors	Kuglstatter, A.,Hennig, M. (deposition date: 2008-01-02, release date: 2008-03-11, Last modification date: 2021-11-10)
Primary citation	Kuglstatter, A.,Stahl, M.,Peters, J.U.,Huber, W.,Stihle, M.,Schlatter, D.,Benz, J.,Ruf, A.,Roth, D.,Enderle, T.,Hennig, M. Tyramine fragment binding to BACE-1 Bioorg.Med.Chem.Lett., 18:1304-1307, 2008 Cited by PubMed: 18226904 DOI: 10.1016/j.bmcl.2008.01.032 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation