3BT2

Structure of urokinase receptor, urokinase and vitronectin complex

3BT2 の概要

• エントリーDOI: 10.2210/pdb3bt2/pdb
• 関連するPDBエントリー: 2fd6 3BT1
• 分子名称: Urokinase-type plasminogen activator, Vitronectin, anti-uPAR antibody, light chain, ... (8 entities in total)
• 機能のキーワード: protein-protein interaction, glycoprotein, gpi-anchor, lipoprotein, membrane, receptor, secreted, blood coagulation, egf-like domain, fibrinolysis, hydrolase, kringle, phosphoprotein, plasminogen activation, protease, serine protease, zymogen, cell adhesion, heparin-binding, sulfation, immunoglobulin domain, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 98915.33

構造登録者

Huang, M. (登録日: 2007-12-27, 公開日: 2008-03-25, 最終更新日: 2024-11-13)

主引用文献

Huai, Q.,Zhou, A.,Lin, L.,Mazar, A.P.,Parry, G.C.,Callahan, J.,Shaw, D.E.,Furie, B.,Furie, B.C.,Huang, M.
Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes
Nat.Struct.Mol.Biol., 15:422-423, 2008

PubMed Abstract: The urokinase receptor (uPAR) can recognize several ligands. The structural basis for this multiple ligand recognition by uPAR is unknown. This study reports the crystal structures of uPAR in complex with both urokinase (uPA) and vitronectin and reveal that uPA occupies the central cavity of the receptor, whereas vitronectin binds at the outer side of the receptor. These results provide a structural understanding of one receptor binding to two ligands.

PubMed: 18376415
DOI: 10.1038/nsmb.1404

実験手法

X-RAY DIFFRACTION (2.5 Å)