3BSC
Crystal Structure of HCV NS5B Polymerase with a Novel Pyridazinone Inhibitor
3BSC の概要
エントリーDOI | 10.2210/pdb3bsc/pdb |
関連するPDBエントリー | 3BR9 3BSA |
分子名称 | RNA-directed RNA polymerase, 5-hydroxy-4-(7-methoxy-1,1-dioxido-2H-1,2,4-benzothiadiazin-3-yl)-2-(3-methylbutyl)-6-phenylpyridazin-3(2H)-one (3 entities in total) |
機能のキーワード | protein-ligand complex, rna replication, rna-binding, rna-directed rna polymerase, transcription, transcription regulation, transferase, transmembrane, viral nucleoprotein |
由来する生物種 | Hepatitis C virus (isolate BK) |
細胞内の位置 | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26663 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 129628.53 |
構造登録者 | Zhao, Q.,Showalter, R.E.,Han, Q.,Kissinger, C.R. (登録日: 2007-12-23, 公開日: 2008-12-23, 最終更新日: 2024-04-03) |
主引用文献 | Zhou, Y.,Webber, S.E.,Murphy, D.E.,Li, L.S.,Dragovich, P.S.,Tran, C.V.,Sun, Z.,Ruebsam, F.,Shah, A.M.,Tsan, M.,Showalter, R.E.,Patel, R.,Li, B.,Zhao, Q.,Han, Q.,Hermann, T.,Kissinger, C.R.,Lebrun, L.,Sergeeva, M.V.,Kirkovsky, L. Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine. Bioorg.Med.Chem.Lett., 18:1413-1418, 2008 Cited by PubMed: 18242088DOI: 10.1016/j.bmcl.2008.01.007 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.65 Å) |
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