3BRH
Protein Tyrosine Phosphatase PTPN-22 (Lyp) bound to the mono-Phosphorylated Lck active site peptide
Summary for 3BRH
Entry DOI | 10.2210/pdb3brh/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 22, Lck Active Site Peptide, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | lyp, ptpn22, phosphatase, lck, alternative splicing, cytoplasm, hydrolase, polymorphism, protein phosphatase, systemic lupus erythematosus |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm : Q9Y2R2 |
Total number of polymer chains | 4 |
Total formula weight | 74719.07 |
Authors | Seidel, R.D.,Love, J.,Piserchio, A.,Cowburn, D. (deposition date: 2007-12-21, release date: 2009-02-17, Last modification date: 2024-02-21) |
Primary citation | Seidel, R.,Love, J.,Piserchio, A.,Cowburn, D. Lyp/PTPN22 Phosphatase Domain: Substrate Recognition and Specificity for Src family kinases To be Published, |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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