3BRH

Protein Tyrosine Phosphatase PTPN-22 (Lyp) bound to the mono-Phosphorylated Lck active site peptide

Summary for 3BRH

• Entry DOI: 10.2210/pdb3brh/pdb
• Descriptor: Tyrosine-protein phosphatase non-receptor type 22, Lck Active Site Peptide, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: lyp, ptpn22, phosphatase, lck, alternative splicing, cytoplasm, hydrolase, polymorphism, protein phosphatase, systemic lupus erythematosus
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm : Q9Y2R2
• Total number of polymer chains: 4
• Total formula weight: 74719.07

Authors

Seidel, R.D.,Love, J.,Piserchio, A.,Cowburn, D. (deposition date: 2007-12-21, release date: 2009-02-17, Last modification date: 2024-02-21)

• Primary citation: Seidel, R.,Love, J.,Piserchio, A.,Cowburn, D.; Lyp/PTPN22 Phosphatase Domain: Substrate Recognition and Specificity for Src family kinases; To be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)