3BPF

Crystal Structure of Falcipain-2 with Its inhibitor, E64

Summary for 3BPF

Entry DOI	10.2210/pdb3bpf/pdb
Related	1AIM 1YVB 2GHU 3BPM
Descriptor	Cysteine protease falcipain-2, N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE, GLYCEROL, ... (4 entities in total)
Functional Keywords	falcipain, malaria, cysteine protease, hydrolase, thiol protease
Biological source	Plasmodium falciparum
Total number of polymer chains	4
Total formula weight	110280.50
Authors	kerr, I.D.,Lee, J.H.,Brinen, L.S. (deposition date: 2007-12-18, release date: 2008-12-30, Last modification date: 2023-08-30)
Primary citation	Kerr, I.D.,Lee, J.H.,Pandey, K.C.,Harrison, A.,Sajid, M.,Rosenthal, P.J.,Brinen, L.S. Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity. J.Med.Chem., 52:852-857, 2009 Cited by PubMed: 19128015 DOI: 10.1021/jm8013663 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation