3BP4

The high resolution crystal structure of HLA-B*2705 in complex with a Cathepsin A signal sequence peptide pCatA

3BP4 の概要

• エントリーDOI: 10.2210/pdb3bp4/pdb
• 関連するPDBエントリー: 3BP7
• 分子名称: HLA class I histocompatibility antigen, B-27 alpha chain, Beta-2-microglobulin, nonameric peptide from Lysosomal protective protein, ... (5 entities in total)
• 機能のキーワード: major histocompatibility complex, mhc, human leukocyte antigen, hla, beta-2-microglobulin, b2m, cathepsin a, pcata, ankylosing spondylitis, glycoprotein, host-virus interaction, immune response, membrane, mhc i, transmembrane, disease mutation, glycation, immunoglobulin domain, pyrrolidone carboxylic acid, secreted, carboxypeptidase, hydrolase, lysosome, protease, zymogen, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P03989; Secreted . Note=(Microbial infection) In the presence of M: P61769; Lysosome: P10619
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 44973.90

構造登録者

Kumar, P.,Vahedi-Faridi, A.,Saenger, W.,Uchanska-Ziegler, B.,Ziegler, A. (登録日: 2007-12-18, 公開日: 2008-12-23, 最終更新日: 2023-11-01)

• 主引用文献: Kumar, P.,Vahedi-Faridi, A.,Saenger, W.,Merino, E.,Lopez de Castro, J.A.,Uchanska-Ziegler, B.,Ziegler, A.; Structural basis for T cell alloreactivity among three HLA-B14 and HLA-B27 antigens; J.Biol.Chem., 284:29784-29797, 2009; PubMed: 19617632; DOI: 10.1074/jbc.M109.038497

実験手法

X-RAY DIFFRACTION (1.85 Å)