3BLR

Crystal Structure of Human CDK9/cyclinT1 in complex with Flavopiridol

Summary for 3BLR

• Entry DOI: 10.2210/pdb3blr/pdb
• Related: 3BLH 3BLQ
• Descriptor: Cell division protein kinase 9, Cyclin-T1, PHOSPHATE ION, ... (5 entities in total)
• Functional Keywords: transcriptional cdk-cyclin complex, phosphorylated, flavopiridol, alternative splicing, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transcription regulation, transferase, acetylation, cell cycle, cell division, coiled coil, host-virus interaction, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P50750 O60563
• Total number of polymer chains: 2
• Total formula weight: 68860.26

Authors

Baumli, S.,Lolli, G.,Lowe, E.D.,Johnson, L.N. (deposition date: 2007-12-11, release date: 2008-07-01, Last modification date: 2023-11-01)

• Primary citation: Baumli, S.,Lolli, G.,Lowe, E.D.,Troiani, S.,Rusconi, L.,Bullock, A.N.,Debreczeni, J.E.,Knapp, S.,Johnson, L.N.; The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation; Embo J., 27:1907-1918, 2008; PubMed: 18566585; DOI: 10.1038/emboj.2008.121

Experimental method

X-RAY DIFFRACTION (2.8 Å)