3BLR
Crystal Structure of Human CDK9/cyclinT1 in complex with Flavopiridol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cell division protein kinase 9 | polymer | 331 | 38054.1 | 1 | UniProt (P50750) Pfam (PF00069) | Homo sapiens (human) | Cyclin-dependent kinase 9, Serine/threonine-protein kinase PITALRE, C-2K, Cell division cycle 2-like protein kinase 4 |
| 2 | B (B) | Cyclin-T1 | polymer | 260 | 30119.4 | 1 | UniProt (O60563) Pfam (PF00134) Pfam (PF21797) | Homo sapiens (human) | CycT1, Cyclin-T |
| 3 | C, E, F (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 3 | Chemie (PO4) | |||
| 4 | D (A) | 2-(2-CHLORO-PHENYL)-5,7-DIHYDROXY-8-(3-HYDROXY-1-METHYL-PIPERIDIN-4-YL)-4H-BENZOPYRAN-4-ONE | non-polymer | 401.8 | 1 | Chemie (CPB) | |||
| 5 | G, H (A, B) | water | water | 18.0 | 20 | Chemie (HOH) |
Sequence modifications
A: 2 - 330 (UniProt: P50750)
B: 2 - 259 (UniProt: O60563)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Pro 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Pro 1 | - | expression tag |
| Arg 77 | Gln 77 | engineered mutation |
| Gly 96 | Glu 96 | engineered mutation |
| Leu 241 | Phe 241 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 68173.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 686.8 | |
| All* | Total formula weight | 68860.3 |
