3BI7

Crystal structure of the SRA domain of E3 ubiquitin-protein ligase UHRF1

3BI7 の概要

• エントリーDOI: 10.2210/pdb3bi7/pdb
• 関連するPDBエントリー: 2FAZ
• 分子名称: E3 ubiquitin-protein ligase UHRF1, SULFATE ION, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: cell cycle, dna damage, dna repair, dna-binding, ligase, metal-binding, nucleus, phosphorylation, polymorphism, transcription, transcription regulation, ubl conjugation, ubl conjugation pathway, zinc, zinc-finger, structural genomics consortium, sgc, phosphoprotein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: Q96T88
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24254.58

構造登録者

Walker, J.R.,Avvakumov, G.V.,Xue, S.,Li, Y.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Dhe-Paganon, S.,Structural Genomics Consortium (SGC) (登録日: 2007-11-30, 公開日: 2007-12-18, 最終更新日: 2011-07-13)

• 主引用文献: Avvakumov, G.V.,Walker, J.R.,Xue, S.,Li, Y.,Duan, S.,Bronner, C.,Arrowsmith, C.H.,Dhe-Paganon, S.; Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1.; Nature, 455:822-826, 2008; PubMed: 18772889; DOI: 10.1038/nature07273

実験手法

X-RAY DIFFRACTION (1.7 Å)