3BGL

Hepatoselectivity of Statins: Design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors

3BGL の概要

• エントリーDOI: 10.2210/pdb3bgl/pdb
• 関連するPDBエントリー: 2Q1L 2Q6B 2Q6C 2R4F
• 分子名称: 3-hydroxy-3-methylglutaryl-coenzyme A reductase, (3R,5R)-7-[2-(4-fluorophenyl)-5-(1-methylethyl)-4-(morpholin-4-ylsulfonyl)-3-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid (3 entities in total)
• 機能のキーワード: oxidoreductase, cholesterol biosynthesis, hmg-coa, nadph, statin, alternative splicing, endoplasmic reticulum, glycoprotein, lipid synthesis, membrane, peroxisome, polymorphism, steroid biosynthesis, transmembrane
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane; Multi-pass membrane protein: P04035
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 192272.95

構造登録者

Finzel, B.C.,Pavlovsky, A.,Park, W.K.C. (登録日: 2007-11-26, 公開日: 2008-01-29, 最終更新日: 2024-02-21)

• 主引用文献: Park, W.K.,Kennedy, R.M.,Larsen, S.D.,Miller, S.,Roth, B.D.,Song, Y.,Steinbaugh, B.A.,Sun, K.,Tait, B.D.,Kowala, M.C.,Trivedi, B.K.,Auerbach, B.,Askew, V.,Dillon, L.,Hanselman, J.C.,Lin, Z.,Lu, G.H.,Robertson, A.,Sekerke, C.; Hepatoselectivity of statins: design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors.; Bioorg.Med.Chem.Lett., 18:1151-1156, 2008; PubMed: 18155906; DOI: 10.1016/j.bmcl.2007.11.124

実験手法

X-RAY DIFFRACTION (2.225 Å)