3BGB

HIV-1 protease in complex with a isobutyl decorated oligoamine

3BGB の概要

• エントリーDOI: 10.2210/pdb3bgb/pdb
• 関連するPDBエントリー: 3BGC
• 分子名称: Protease, N,N'-(iminodiethane-2,1-diyl)bis[4-amino-N-(2-methylpropyl)benzenesulfonamide], CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: protein-ligand complex, aids, aspartyl protease, capsid maturation, core protein, cytoplasm, dna integration, dna recombination, dna-directed dna polymerase, endonuclease, hydrolase, lipoprotein, magnesium, membrane, metal-binding, multifunctional enzyme, myristate, nuclease, nucleotidyltransferase, nucleus, phosphoprotein, protease, rna-binding, rna-directed dna polymerase, transferase, viral nucleoprotein, virion, zinc, zinc-finger
• 由来する生物種: Human immunodeficiency virus type 1 (Viruses)
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22204.15

構造登録者

Boettcher, J.,Blum, A.,Sammet, B.,Heine, A.,Diederich, W.E.,Klebe, G. (登録日: 2007-11-26, 公開日: 2008-09-02, 最終更新日: 2023-11-01)

• 主引用文献: Blum, A.,Sammet, B.,Luksch, T.,Heine, A.,Klebe, G.,Diederich, W.E.; Achiral oligoamines as versatile tool for the development of aspartic protease inhibitors; Bioorg.Med.Chem., 16:8574-8586, 2008; PubMed: 18760609; DOI: 10.1016/j.bmc.2008.08.012

実験手法

X-RAY DIFFRACTION (1.9 Å)