3BG4

The crystal structure of guamerin in complex with chymotrypsin and the development of an elastase-specific inhibitor

Summary for 3BG4

Entry DOI	10.2210/pdb3bg4/pdb
Descriptor	Chymotrypsin A chain A, Chymotrypsin A chain B, Chymotrypsin A chain C, ... (5 entities in total)
Functional Keywords	guamerin, chymotrypsin, elastase, inhibitor, digestion, hydrolase, protease, secreted, serine protease, zymogen, protease inhibitor, serine protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Hirudo nipponia (Leech) More
Cellular location	Secreted, extracellular space: P00766 P00766 P00766 Secreted: P46443
Total number of polymer chains	4
Total formula weight	31389.47
Authors	Kim, H.,Chu, T.T.T.,Kim, D.Y.,Kim, D.R.,Nguyen, C.M.T.,Choi, J.,Lee, J.R.,Hahn, M.J.,Kim, K.K. (deposition date: 2007-11-26, release date: 2008-07-29, Last modification date: 2023-11-01)
Primary citation	Kim, H.,Chu, T.T.T.,Kim, D.Y.,Kim, D.R.,Nguyen, C.M.T.,Choi, J.,Lee, J.R.,Hahn, M.J.,Kim, K.K. The crystal structure of guamerin in complex with chymotrypsin and the development of an elastase-specific inhibitor. J.Mol.Biol., 376:184-192, 2008 Cited by PubMed: 18155725 DOI: 10.1016/j.jmb.2007.11.089 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation