3BEG

Crystal structure of SR protein kinase 1 complexed to its substrate ASF/SF2

3BEG の概要

• エントリーDOI: 10.2210/pdb3beg/pdb
• 分子名称: Serine/threonine-protein kinase SRPK1, Splicing factor, arginine/serine-rich 1, PHOSPHOSERINE, ... (5 entities in total)
• 機能のキーワード: kinase, sr protein kinase, sr protein, pre-mrna splicing, atp-binding, chromosome partition, differentiation, mrna processing, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase, methylation, rna-binding, spliceosome, transferase-splicing complex, transferase/splicing
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cytoplasm: Q96SB4; Cytoplasm : Q07955
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 57183.68

構造登録者

Ngo, J.C.,Giang, K.,Chakrabarti, S.,Ma, C.-T.,Huynh, N.,Hagopian, J.,Dorrestein, P.C.,Fu, X.-D.,Adams, J.A.,Ghosh, G. (登録日: 2007-11-18, 公開日: 2008-04-01, 最終更新日: 2024-02-21)

• 主引用文献: Ngo, J.C.,Giang, K.,Chakrabarti, S.,Ma, C.-T.,Huynh, N.,Hagopian, J.,Dorrestein, P.C.,Fu, X.-D.,Adams, J.A.,Ghosh, G.; A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1; Mol.Cell, 29:563-576, 2008; PubMed: 18342604; DOI: 10.1016/j.molcel.2007.12.017

実験手法

X-RAY DIFFRACTION (2.9 Å)