3BEC

Crystal structure of E. coli penicillin-binding protein 5 in complex with a peptide-mimetic cephalosporin

3BEC の概要

• エントリーDOI: 10.2210/pdb3bec/pdb
• 関連するPDBエントリー: 3BEB
• 分子名称: Penicillin-binding protein 5, GLYCEROL, (2R)-2-[(R)-{[(6S)-6-amino-6-carboxyhexanoyl]amino}(carboxy)methyl]-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: peptidoglycan synthesis, penicillin-binding protein, dd-carboxypeptidase, hydrolase, designed cephalosporin, cell shape, cell wall biogenesis/degradation, inner membrane, membrane, protease
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side: P0AEB2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40598.92

構造登録者

Powell, A.J.,Davies, C. (登録日: 2007-11-16, 公開日: 2008-08-26, 最終更新日: 2023-08-30)

• 主引用文献: Sauvage, E.,Powell, A.J.,Heilemann, J.,Josephine, H.R.,Charlier, P.,Davies, C.,Pratt, R.F.; Crystal structures of complexes of bacterial DD-peptidases with peptidoglycan-mimetic ligands: the substrate specificity puzzle; J.Mol.Biol., 381:383-393, 2008; PubMed: 18602645; DOI: 10.1016/j.jmb.2008.06.012

実験手法

X-RAY DIFFRACTION (1.6 Å)