3BEA

cFMS tyrosine kinase (tie2 KID) in complex with a pyrimidinopyridone inhibitor

Summary for 3BEA

• Entry DOI: 10.2210/pdb3bea/pdb
• Related: 2I0v 2I0y 2I1m 2ogv
• Descriptor: Macrophage colony-stimulating factor 1 receptor, SULFATE ION, 8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]phenyl}amino)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide, ... (4 entities in total)
• Functional Keywords: kinase domain, inhibitor, transferase, juxtamembrane domain, atp-binding, glycoprotein, immunoglobulin domain, nucleotide-binding, phosphoprotein, polymorphism, proto-oncogene, receptor, transmembrane, tyrosine-protein kinase
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein: P07333
• Total number of polymer chains: 1
• Total formula weight: 38452.94

Authors

Schubert, C. (deposition date: 2007-11-16, release date: 2008-07-15, Last modification date: 2023-08-30)

Primary citation

Huang, H.,Hutta, D.A.,Hu, H.,DesJarlais, R.L.,Schubert, C.,Petrounia, I.P.,Chaikin, M.A.,Manthey, C.L.,Player, M.R.
Design and synthesis of a pyrido[2,3-d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors.
Bioorg.Med.Chem.Lett., 18:2355-2361, 2008

PubMed Abstract: A series of pyrimidinopyridones has been designed, synthesized and shown to be potent and selective inhibitors of the FMS tyrosine kinase. Introduction of an amide substituent at the 6-position of the pyridone core resulted in a significant potency increase. Compound 24 effectively inhibited in vivo LPS-induced TNF in mice greater than 80%.

PubMed: 18342505
DOI: 10.1016/j.bmcl.2008.02.070

Experimental method

X-RAY DIFFRACTION (2.02 Å)