3BDJ

Crystal Structure of Bovine Milk Xanthine Dehydrogenase with a Covalently Bound Oxipurinol Inhibitor

3BDJ の概要

• エントリーDOI: 10.2210/pdb3bdj/pdb
• 分子名称: Xanthine dehydrogenase/oxidase, CALCIUM ION, FE2/S2 (INORGANIC) CLUSTER, ... (10 entities in total)
• 機能のキーワード: oxypurinol, oxipurinol, alloxanthine, allopurinol, covalently bound inhibitor, xanthine oxidase, xanthine oxidoreductase, xanthine dehydrogenase, fad, flavoprotein, iron-sulfur, molybdopterin, peroxisome, oxidoreductase
• 由来する生物種: Bos taurus (Bovine)
• 細胞内の位置: Cytoplasm (By similarity): P80457
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 298490.44

構造登録者

Eger, B.T.,Okamoto, K.,Nishino, T.,Pai, E.F.,Nishino, T. (登録日: 2007-11-14, 公開日: 2008-11-25, 最終更新日: 2023-08-30)

• 主引用文献: Okamoto, K.,Eger, B.T.,Nishino, T.,Pai, E.F.,Nishino, T.; Mechanism of inhibition of xanthine oxidoreductase by allopurinol: crystal structure of reduced bovine milk xanthine oxidoreductase bound with oxipurinol.; Nucleosides Nucleotides Nucleic Acids, 27:888-893, 2008; PubMed: 18600558; DOI: 10.1080/15257770802146577

実験手法

X-RAY DIFFRACTION (2 Å)