3BCJ

Crystal structure of Aldose Reductase complexed with 2S4R (Stereoisomer of Fidarestat, 2S4S) at 0.78 A

3BCJ の概要

• エントリーDOI: 10.2210/pdb3bcj/pdb
• 関連するPDBエントリー: 1PWM 1X98
• 分子名称: Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CITRIC ACID, ... (5 entities in total)
• 機能のキーワード: aldo-keto reductases, diabetes, drug design, polyl pathway, acetylation, cataract, cytoplasm, nadp, oxidoreductase, polymorphism
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P15121
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37113.09

構造登録者

Zhao, H.T.,El-Kabbani, O. (登録日: 2007-11-13, 公開日: 2008-04-08, 最終更新日: 2023-11-01)

• 主引用文献: Zhao, H.T.,Hazemann, I.,Mitschler, A.,Carbone, V.,Joachimiak, A.,Ginell, S.,Podjarny, A.,El-Kabbani, O.; Unusual Binding Mode of the 2S4R Stereoisomer of the Potent Aldose Reductase Cyclic Imide Inhibitor Fidarestat (2S4S) in the 15 K Crystal Structure of the Ternary Complex Refined at 0.78 A Resolution: Implications for the Inhibition Mechanism; J.Med.Chem., 51:1478-1481, 2008; PubMed: 18284183; DOI: 10.1021/jm701514k

実験手法

X-RAY DIFFRACTION (0.78 Å)