Summary for 3BC5
| Descriptor | Peroxisome proliferator-activated receptor gamma, (5-{3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]benzyl}-2-phenyl-2H-1,2,3-triazol-4-yl)acetic acid (3 entities in total) |
|---|---|
| Functional Keywords | ligand-binding domain, nuclear hormone receptor, transcription factor, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphorylation, polymorphism, transcription regulation, zinc, zinc-finger, transcription |
| Biological source | Homo sapiens (Human) |
| Cellular location | Nucleus P37231 |
| Total number of polymer chains | 1 |
| Total molecular weight | 34246.61 |
| Authors | Muckelbauer, J.K. (deposition date: 2007-11-12, release date: 2008-11-18, Last modification date: 2017-08-23) |
| Primary citation | Zhang, H.,Ryono, D.E.,Devasthale, P.,Wang, W.,O'Malley, K.,Farrelly, D.,Gu, L.,Harrity, T.,Cap, M.,Chu, C.,Locke, K.,Zhang, L.,Lippy, J.,Kunselman, L.,Morgan, N.,Flynn, N.,Moore, L.,Hosagrahara, V.,Zhang, L.,Kadiyala, P.,Xu, C.,Doweyko, A.M.,Bell, A.,Chang, C.,Muckelbauer, J.,Zahler, R.,Hariharan, N.,Cheng, P.T. Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists. Bioorg.Med.Chem.Lett., 19:1451-1456, 2009 PubMed: 19201606 (PDB entries with the same primary citation) DOI: 10.1016/j.bmcl.2009.01.030  Import into Mendeley |
| Experimental method | X-RAY DIFFRACTION (2.27 Å) |
| NMR Information |
