3BC4
I84V HIV-1 protease in complex with a pyrrolidine diester
Summary for 3BC4
Entry DOI | 10.2210/pdb3bc4/pdb |
Descriptor | protease, 2-aminoethyl naphthalen-1-ylacetate, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | protein-ligand complex, aids, aspartyl protease, capsid maturation, core protein, cytoplasm, dna integration, dna recombination, dna-directed dna polymerase, endonuclease, hydrolase, lipoprotein, magnesium, membrane, metal-binding, multifunctional enzyme, myristate, nuclease, nucleotidyltransferase, nucleus, phosphoprotein, protease, rna-binding, rna-directed dna polymerase, transferase, viral nucleoprotein, virion, zinc, zinc-finger |
Biological source | Human immunodeficiency virus type 1 (Viruses) |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367 |
Total number of polymer chains | 1 |
Total formula weight | 11326.41 |
Authors | Boettcher, J.,Blum, A.,Heine, A.,Diederich, W.E.,Klebe, G. (deposition date: 2007-11-12, release date: 2008-09-02, Last modification date: 2023-11-01) |
Primary citation | Blum, A.,Heine, A.,Diederich, W.E.,Klebe, G. Targeting the open-flap conformation of HIV-1 protease with pyrrolidine-based inhibitors Chemmedchem, 3:1337-1344, 2008 Cited by PubMed: 18720485DOI: 10.1002/cmdc.200800113 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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