3BC4

I84V HIV-1 protease in complex with a pyrrolidine diester

3BC4 の概要

• エントリーDOI: 10.2210/pdb3bc4/pdb
• 分子名称: protease, 2-aminoethyl naphthalen-1-ylacetate, DIMETHYL SULFOXIDE, ... (4 entities in total)
• 機能のキーワード: protein-ligand complex, aids, aspartyl protease, capsid maturation, core protein, cytoplasm, dna integration, dna recombination, dna-directed dna polymerase, endonuclease, hydrolase, lipoprotein, magnesium, membrane, metal-binding, multifunctional enzyme, myristate, nuclease, nucleotidyltransferase, nucleus, phosphoprotein, protease, rna-binding, rna-directed dna polymerase, transferase, viral nucleoprotein, virion, zinc, zinc-finger
• 由来する生物種: Human immunodeficiency virus type 1 (Viruses)
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11326.41

構造登録者

Boettcher, J.,Blum, A.,Heine, A.,Diederich, W.E.,Klebe, G. (登録日: 2007-11-12, 公開日: 2008-09-02, 最終更新日: 2023-11-01)

• 主引用文献: Blum, A.,Heine, A.,Diederich, W.E.,Klebe, G.; Targeting the open-flap conformation of HIV-1 protease with pyrrolidine-based inhibitors; Chemmedchem, 3:1337-1344, 2008; PubMed: 18720485; DOI: 10.1002/cmdc.200800113

実験手法

X-RAY DIFFRACTION (1.82 Å)