3BBB
Crystal structure of the NM23-H2 transcription factor complex with dinucleotide d(AG)
Summary for 3BBB
Entry DOI | 10.2210/pdb3bbb/pdb |
Related | 1NUE 3BBC 3BBF |
Descriptor | Nucleoside diphosphate kinase B, DNA (5'-D(*AP*G)-3') (3 entities in total) |
Functional Keywords | transcription factor, cancer, nm23 gen, hexamer, activator, anti-oncogene, atp-binding, cell cycle, dna-binding, kinase, magnesium, metal-binding, nucleotide metabolism, nucleotide-binding, nucleus, phosphorylation, transcription regulation, transferase |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P22392 |
Total number of polymer chains | 10 |
Total formula weight | 105546.97 |
Authors | Weichsel, A.,Montfort, W.R. (deposition date: 2007-11-09, release date: 2008-09-23, Last modification date: 2024-05-29) |
Primary citation | Dexheimer, T.S.,Carey, S.S.,Zuohe, S.,Gokhale, V.M.,Hu, X.,Murata, L.B.,Maes, E.M.,Weichsel, A.,Sun, D.,Meuillet, E.J.,Montfort, W.R.,Hurley, L.H. NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III1. Mol.Cancer Ther., 8:1363-1377, 2009 Cited by PubMed: 19435876DOI: 10.1158/1535-7163.MCT-08-1093 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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