3B7J

Crystal structure of (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase(FabZ) from Helicobacter pylori complexed with juglone

3B7J の概要

• エントリーDOI: 10.2210/pdb3b7j/pdb
• 関連するPDBエントリー: 2GLL 2GLM 2GLP 2GLV
• 分子名称: (3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ... (5 entities in total)
• 機能のキーワード: fabz complex, juglone, cytoplasm, lipid a biosynthesis, lipid synthesis, lyase
• 由来する生物種: Helicobacter pylori (Campylobacter pylori)
• 細胞内の位置: Cytoplasm (By similarity): Q5G940
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 110638.80

構造登録者

Zhang, L.,Kong, Y.H.,Wu, D.,Shen, X.,Jiang, H.L. (登録日: 2007-10-31, 公開日: 2008-09-02, 最終更新日: 2023-11-01)

• 主引用文献: Kong, Y.H.,Zhang, L.,Yang, Z.Y.,Han, C.,Hu, L.H.,Jiang, H.L.,Shen, X.; Natural product juglone targets three key enzymes from Helicobacter pylori: inhibition assay with crystal structure characterization; ACTA PHARMACOL.SIN., 29:870-876, 2008; PubMed: 18565285; DOI: 10.1111/j.1745-7254.2008.00808.x

実験手法

X-RAY DIFFRACTION (2.4 Å)