3B6H

Crystal structure of human prostacyclin synthase in complex with inhibitor minoxidil

3B6H の概要

• エントリーDOI: 10.2210/pdb3b6h/pdb
• 関連するPDBエントリー: 2iag 3B98 3B99
• 分子名称: Prostacyclin synthase, octyl beta-D-glucopyranoside, 6-PIPERIDIN-1-YLPYRIMIDINE-2,4-DIAMINE 3-OXIDE, ... (5 entities in total)
• 機能のキーワード: prostacyclin synthase, enzyme-inhibitor complex, cyp8a1, cytochrome p450, endoplasmic reticulum, fatty acid biosynthesis, heme, iron, isomerase, lipid synthesis, membrane, metal-binding, polymorphism, prostaglandin biosynthesis, transmembrane
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 116779.52

構造登録者

Li, Y.-C.,Chiang, C.-W.,Yeh, H.-C.,Hsu, P.-Y.,Whitby, F.G.,Wang, L.-H.,Chan, N.-L. (登録日: 2007-10-29, 公開日: 2007-11-20, 最終更新日: 2023-11-01)

• 主引用文献: Li, Y.-C.,Chiang, C.-W.,Yeh, H.-C.,Hsu, P.-Y.,Whitby, F.G.,Wang, L.-H.,Chan, N.-L.; Structures of Prostacyclin Synthase and Its Complexes with Substrate Analog and Inhibitor Reveal a Ligand-specific Heme Conformation Change; J.Biol.Chem., 283:2917-2926, 2008; PubMed: 18032380; DOI: 10.1074/jbc.M707470200

実験手法

X-RAY DIFFRACTION (1.62 Å)