3B6G

Nucleosome core particle treated with oxaliplatin

Summary for 3B6G

• Entry DOI: 10.2210/pdb3b6g/pdb
• Related: 1KX5 3B6F
• Descriptor: 147-MER DNA, Histone H3.2, Histone H4, ... (7 entities in total)
• Functional Keywords: nucleosome, chromatin, platinum adduct, oxaliplatin, anti-cancer, drug, acetylation, chromosomal protein, dna-binding, methylation, nucleosome core, nucleus, phosphorylation, ubl conjugation, structural protein-dna complex, structural protein/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P84233 P62799 P02281; Nucleus (By similarity): Q6AZJ8
• Total number of polymer chains: 10
• Total formula weight: 199426.87

Authors

Wu, B.,Davey, C.A. (deposition date: 2007-10-29, release date: 2007-12-25, Last modification date: 2023-11-01)

Primary citation

Wu, B.,Droge, P.,Davey, C.A.
Site selectivity of platinum anticancer therapeutics
Nat.Chem.Biol., 4:110-112, 2008

PubMed Abstract: X-ray crystallographic and biochemical investigation of the reaction of cisplatin and oxaliplatin with nucleosome core particle and naked DNA reveals that histone octamer association can modulate DNA platination. Adduct formation also occurs at specific histone methionine residues, which could serve as a nuclear platinum reservoir influencing adduct transfer to DNA. Our findings suggest that the nucleosome center may provide a favorable target for the design of improved platinum anticancer drugs.

PubMed: 18157123
DOI: 10.1038/nchembio.2007.58

Experimental method

X-RAY DIFFRACTION (3.45 Å)