3B5G

Crystal Structure of the Unstable and Highly Fibrillogenic PRO7SER Mutant of the Recombinant Variable Domain 6AJL2

Summary for 3B5G

Entry DOI	10.2210/pdb3b5g/pdb
Descriptor	AMYLOID LAMBDA 6 LIGHT CHAIN VARIABLE REGION PIP, ACETATE ION, GLYCEROL, ... (5 entities in total)
Functional Keywords	lambda vi subgroup, light chain variable domain, beta-sandwich, immunoglobulin, al amyloidosis, immune system
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	24689.48
Authors	Hernandez-Santoyo, A.,Rodriguez-Romero, A. (deposition date: 2007-10-25, release date: 2008-11-04, Last modification date: 2023-08-30)
Primary citation	Hernandez-Santoyo, A.,del Pozo Yauner, L.,Fuentes-Silva, D.,Ortiz, E.,Rudino-Pinera, E.,Sanchez-Lopez, R.,Horjales, E.,Becerril, B.,Rodriguez-Romero, A. A single mutation at the sheet switch region results in conformational changes favoring lambda6 light-chain fibrillogenesis. J.Mol.Biol., 396:280-292, 2010 Cited by PubMed: 19941869 DOI: 10.1016/j.jmb.2009.11.038 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation