3B5B

Crystal structure of the thymidylate synthase k48q

3B5B の概要

• エントリーDOI: 10.2210/pdb3b5b/pdb
• 分子名称: Thymidylate synthase, 2'-DEOXY-5-NITROURIDINE 5'-MONOPHOSPHATE, FORMIC ACID, ... (5 entities in total)
• 機能のキーワード: thymidylate synthase, 5-no2-dump, substrate anologue, methyltransferase, nucleotide biosynthesis, repressor, rna-binding, transferase, translation regulation
• 由来する生物種: Escherichia coli BL21
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 61829.63

構造登録者

Sotelo-Mundo, R.R.,Arreola, R.,Maley, F.,Montfort, W.R. (登録日: 2007-10-25, 公開日: 2007-12-25, 最終更新日: 2023-08-30)

• 主引用文献: Arvizu-Flores, A.A.,Sugich-Miranda, R.,Arreola, R.,Garcia-Orozco, K.D.,Velazquez-Contreras, E.F.,Montfort, W.R.,Maley, F.,Sotelo-Mundo, R.R.; Role of an invariant lysine residue in folate binding on Escherichia coli thymidylate synthase: Calorimetric and crystallographic analysis of the K48Q mutant.; Int.J.Biochem.Cell Biol., 40:2206-2217, 2008; PubMed: 18403248; DOI: 10.1016/j.biocel.2008.02.025

実験手法

X-RAY DIFFRACTION (2.7 Å)