3B2T

Structure of phosphotransferase

3B2T の概要

• エントリーDOI: 10.2210/pdb3b2t/pdb
• 分子名称: Fibroblast growth factor receptor 2, PHOSPHATE ION, 5'-O-[(S)-hydroxy{[(S)-hydroxy(methyl)phosphoryl]oxy}phosphoryl]adenosine, ... (4 entities in total)
• 機能のキーワード: phosphotransferase, cell signaling, alternative splicing, atp-binding, disease mutation, ectodermal dysplasia, glycoprotein, heparin-binding, immunoglobulin domain, kinase, lacrimo-auriculo-dento-digital syndrome, membrane, nucleotide-binding, phosphorylation, polymorphism, receptor, secreted, transmembrane, tyrosine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72530.58

構造登録者

Lew, E.D.,Bae, J.H.,Rohmann, E.,Wollnik, B.,Schlessinger, J. (登録日: 2007-10-19, 公開日: 2008-02-26, 最終更新日: 2023-08-30)

• 主引用文献: Lew, E.D.,Bae, J.H.,Rohmann, E.,Wollnik, B.,Schlessinger, J.; Structural basis for reduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition and activation.; Proc.Natl.Acad.Sci.Usa, 104:19802-19807, 2007; PubMed: 18056630; DOI: 10.1073/pnas.0709905104

実験手法

X-RAY DIFFRACTION (1.8 Å)