3B28
Hsp90 alpha N-terminal domain in complex with an inhibitor CH5015765
Summary for 3B28
Entry DOI | 10.2210/pdb3b28/pdb |
Related | 3B24 3B25 3B26 3B27 |
Descriptor | Heat shock protein HSP 90-alpha, GLYCEROL, 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(methylsulfanyl)-1,3,5-triazin-2-amine, ... (5 entities in total) |
Functional Keywords | chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P07900 |
Total number of polymer chains | 2 |
Total formula weight | 52406.27 |
Authors | Fukami, T.A.,Ono, N. (deposition date: 2011-07-21, release date: 2011-09-14, Last modification date: 2024-03-13) |
Primary citation | Miura, T.,Fukami, T.A.,Hasegawa, K.,Ono, N.,Suda, A.,Shindo, H.,Yoon, D.O.,Kim, S.J.,Na, Y.J.,Aoki, Y.,Shimma, N.,Tsukuda, T.,Shiratori, Y. Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design Bioorg.Med.Chem.Lett., 21:5778-5783, 2011 Cited by PubMed: 21875802DOI: 10.1016/j.bmcl.2011.08.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
Download full validation report