3AXW

Crystal structure of human CK2alpha complexed with a potent inhibitor

Summary for 3AXW

Entry DOI	10.2210/pdb3axw/pdb
Descriptor	Casein kinase II subunit alpha, 4-(5-amino-1,3,4-thiadiazol-2-yl)benzoic acid (3 entities in total)
Functional Keywords	kinase domain, serine/threonine kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	40699.43
Authors	Kinoshita, T.,Nakanishi, I. (deposition date: 2011-04-18, release date: 2012-04-04, Last modification date: 2024-03-13)
Primary citation	Hou, Z.,Nakanishi, I.,Kinoshita, T.,Takei, Y.,Yasue, M.,Misu, R.,Suzuki, Y.,Nakamura, S.,Kure, T.,Ohno, H.,Murata, K.,Kitaura, K.,Hirasawa, A.,Tsujimoto, G.,Oishi, S.,Fujii, N. Structure-Based Design of Novel Potent Protein Kinase CK2 (CK2) Inhibitors with Phenyl-azole Scaffolds J.Med.Chem., 55:2899-2903, 2012 Cited by PubMed: 22339433 DOI: 10.1021/jm2015167 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation